Rs; all were LO NI withConclusions The delayed therapy with ciprofloxacin

Rs; PubMed ID: all were LO NI withConclusions The delayed therapy with ciprofloxacin and piperacillin was effective as a treatment strategy for P. aeruginosainduced pneumonia/sepsis. This therapy increases the validity of our sepsis model.P98 Characterization of an experimental model of septic shock induced by fecal peritonitis in pigsL Azevedo, M Park, A Maciel, D Noritomi, C Mitteldorf, G Schettino Hospital Sirio-Libanes, S Paulo, Brazil Critical Care 2006, 10(Suppl 1):P98 (doi:10.1186/cc4445) Introduction Pathophysiological human studies in sepsis are difficult to perform due to ethical and methodological concerns. In this context, animal models of severe sepsis can be useful to better understand this condition and to test new therapeutic interventions. Objective The purpose of this study was to describe and characterize a clinically relevant experimental model of septic shock in pigs that could be useful to test different therapeutic interventions. Methods Five White Large pigs (35?5 kg) were anesthetized and instrumented with arterial and Swan anz catheters. A splenectomy was performed and sepsis was induced by peritoneal instillation ofSAvailable online prognosis. The most common pathogens were P. aeruginosa, DOTATATE A. baumannii and MRSA (totally 87 ); during the last years the incidence of MRSA-NI increased significantly. A. baumannii was isolated especially in younger patients and almost never in PubMed ID: the elderly. Pneumonias (P < 0.05) and CNSI (P < 0.05) increased MR, while no difference was seen between EO and LO pneumonias.P100 Efficacy and safety of colistin in the treatment of infections in the ICU caused by multidrug-resistant Gram-negative organismsJ Pavleas, A Skiada, K Rigas, K Salatas, G Belivanakis, N Archodoulis, A Mega, P Vernikos, G Thomopoulos Laiko General Hospital, Athens, Greece Critical Care 2006, 10(Suppl 1):P100 (doi:10.1186/cc4447) Background The treatment of infections caused by multidrugresistant (MDR) Gram-negative organisms poses a therapeutic challenge. With a diminishing armamentarium of effective new chemotherapeutic agents, there has been renewed interest in the polymyxins, which had fallen out of favour due to nephrotoxicity and neurotoxicity reported during their use in the 1960s. Aim Epidemiological analysis of the use of colistin in the treatment of MDR infections in an ICU. Patients and methods We prospectively recorded the clinical and microbiological efficacy, and safety profile of colistin (polymyxin E) in the treatment of MDR Gram-negative bacterial infections in an ICU, during a period of 18 months. Patients were treated with intravenous and/or aerosolized colistin. Results Twenty-eight critically ill patients received a total of 33 courses of colistin administered in combination with another antimicrobial agent (mainly carbapenems or -lactamase inhibitors). The patients' mean age was 66 years (range 29?4). Nineteen patients were male and nine female. Their mean APACHE II score was 18 (range 10?9). The infections treated were: 19 pneumonias (of which five had concurrent bacteremia), seven catheter-related bacteremias, three cases of peritonitis, one primary bacteremia, one infection of the catheter tip (without bacteremia) and one urinary tract infection. In one case the use of colistin was empirical. The responsible bacteria were Acinetobacter baumanii (47 ), Pseudomonas aeruginosa (50 ) and Klebsiella pneumonia (3 ). The mean duration of colistin therapy was 14 days (ra.

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