N, defined as 50 decrease in eGFR or eGFR <15 mL/min/1.73 m

N, defined as 50 PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/1418890 decrease in eGFR or eGFR DOTATATE bicarbonate No ?Adjustment for time-varying serum bicarbonate levels ?Data derived from clinical and administrative dataset ?Single measure of serum bicarbonate ?Single measure of serum bicarbonateMenon et al. 2010 [12](1) ESRD (need for dialysis or 1,781 participants (839 randomized, 942 transplantation); (2) all-cause mortality; (3) composite of 1 and 2 non-randomized) from the MDRD study 1,090 participants of the AASK trial Composite outcome of death, ESRD (dialysis or transplantation), or GFR event (defined as a GFR reduction by 50 or by 25 ml/min/1.73 m2 from baseline)HR 1.05 (0.87-1.28), 0.99 (0.75-1.13), 1.04 (0.87-1.24) for need for kidney failure, all-cause mortality, and composite outcome, respectively, for serum bicarbonate 11?0 compared with 26?0 mEq/L HR 0.960 (0.924-0.998) for composite outcome, per mEq/L PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/21804710 higher baseline serum bicarbonateRaphael et al. 2011 [11]Navaneethan 41,749 outpatients et al. 2011 [13] with eGFR < 60 mL/min/1.73 m2 in Cleveland, OH Dobre et al. 2013 [14] 3,939 participants from the CRIC studyAll-cause mortality?Examination of temporal change in serum bicarbonate ?Large sample size ?Well-characterized cohort?Data derived from clinical and administrative dataset ?Single measure of serum bicarbonate(1) Renal outcome, defined as 50 decrease in eGFR or ESRD (dialysis or transplantation); (2) atherosclerotic events; (3) CHF events; (4) all-cause mortality Kidney disease progression, defined as 25 decrease in eGFR or initiation of dialysis All-cause mortalityNoKanda et al. 2013 [15]113 Japanese patients 60 years old with eGFR < 60 mL/min/1.73 m2 15,836 participants of NHANES IIINo?Focus on elderly cohort?Single measure of serum bicarbonate ?Small sample sizeRaphael et al. 2013 [16]HR 1.75 (1.12-2.74), 1.56 (0.78-3.09), and 2.56 (1.49-4.38) for total population, non-CKD, and CKD subgroups, respectively, for serum bicarbonate <22 mEq/L compared with 26?0 mEq/LNo?Nationally representative ?Single measure of serum cohort bicarbonate ?Compared CKD and non-CKD subgroups Page 2 ofAbbreviations: HR, hazard ratio; CI, confidence interval; GFR, glomerular filtration rate; MDRD, Modification of Diet in Renal Disease; AASK, African American Study of Kidney Disease and.

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